Endocrine Abstracts

Introduction: Diabetes Mellitus (DM) is 2–4 times more common in Turner Syndrome (TS) than karyotype normal females. Diagnosis of DM in TS is usually based on age of presentation and insulin dependency without regard for DM- autoimmunity. Previous research has identified DM associations with the isochromosome and ring chromosome. However, only small numbers of diabetics have been included in reports so far. Here we present preliminary data on DM characterisation in TS.</p...

Cancer cells show different metabolic requirements than normal cells, being the high rate of glucose uptake one of the most important aspects. An increase in glucose uptake has been associated mainly with GLUT1 overexpression but may also involve other transporters including GLUT4, whose presence in prostate cancer cells was recently discovered in our laboratory. Moreover, androgens stimulate anabolic synthesis and increase glucose uptake. Despite this, the regulation of GLUT ...

Objective: Microalbuminuria is usually the first microvascular complication of type 1 diabetes mellitus (T1DM). We aimed to identify its frequency, time of occurrence and related risk factors.Methods: Clinical reports of 201 children followed in our institution were retrospectively analysed (diabetes duration 3.8±3.6 years, age at diagnosis 8.1±3.7 years, HbA1c value 9.0±1.7%). Statistical analysis was performed with SPSS version.21 for Wi...

Objective: To describe the clinical characteristics of stroke in patients with prediabetes mellitus (pre-DM) and to compare them with DM and non-DM patient characteristics.Methods: Retrospective analysis of a prospective series of acute stroke patients. Demographic and clinical characteristics were compared among the three groups, along with outcome data. Stroke severity was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale).<p cla...

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale)....

In our centre we use CNB for routine study of thyroid nodules since 2005. Four diagnostic categories for CNB’s results have been standardised: insufficient; benign; follicular proliferation (FOL), including follicular and oncocytic neoplasms; and malignant. Diagnosis of FOL was defined according to the presence of microfollicular patterned biopsies with scant or absent colloid, sometimes with minimal pleomorphism or discrete nuclear changes. This category could be equival...

The full-length retinoblastoma interacting zinc-finger protein (RIZ), codified by ten exons, has tumour suppressive and differentiating properties and is known to be a downstream effector in classical oestrogen target tissue. In many normal and malignant tissues alternative splicing isoforms, RIZ1 and RIZ2, frame-shift mutations and/or exon deletions have been found, but their oncogenic role is still debated. Although the presence of RIZ1 in the testis has been described, in g...

Objective: Transsphenoidal surgery (TSS) presents the treatment of choice for Cushing’s disease (CD), 95% microadenomas. Remission and recurrence rates vary dependent on tumor size, extension, adenoma visibility on magnetic resonance imaging, and neurosurgical expertise. Remission rates in the postoperative vary between 55 and 85%, with a recurrence of up to 25%. The aim of this study was to describe the rate of remission and recurrence of CD in our midst after TSS, and c...

Introduction: Nonclassical congenital adrenal hyperplasia (NCCAH) is caused by reduced 21-hydroxylase activity, leading to excessive adrenal androgens and premature pubarche (PP); idiopathic PP (IPP) is its main differential diagnosis. The gold standard for the differential diagnosis is ACTH stimulation test (ST); this test also estimates the adrenal cortisol reserve in NCCAH patients.Objectives: To compare the clinical characteristics and baseline hormo...

The actin binding protein filamin A (FLNA) is required for somatostatin receptor 2 (SST2) and dopamine receptor 2 (DRD2) expression, intracellular localization and signaling in GH- and PRL-secreting pituitary tumors, respectively, playing a role in tumor responsiveness to somatostatin analogs and dopaminergic drugs. FLNA functions are tightly regulated by several mechanisms, including FLNA phosphorylation. It has recently been shown that in GH-secreting pituitary tumors FLNA p...